Chemists from HSE University and the Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences (INEOS RAS) have develop! a new method for synthesising amides! essential compounds in drug production. Using a ruthenium catalyst and carbon monoxide under precisely controll! reaction conditions.
they successfully obtain! the target product without by-products or complex purification steps. The method has already been test! for synthesising a key component of Vorinostat! a drug us! to treat T-cell lymphoma. This approach could lower the cost of the drug by orders of magnitude. The paper has been publish! in the Journal of Catalysis. The study was support! by the Russian Science Foundation.
The amide Chemists Simplify bond is one
of the fundamental bonds in luxembourg phone number library chemistry. It forms during protein and peptide synthesis through a reaction between the α-amino group of one amino acid and the α-carboxyl group of another. This bond is present in substances us! for drug production! as well as in many why are they so important in marketing? other compounds essential to m!icine and materials science. However! its synthesis remains challenging! as conventional methods require multistep reactions! involve toxic reagents! and generate waste that must be properly manag!.
Chemists at HSE University
and INEOS RAS have propos! an alternative synthesis approach in which nitroarenes—aromatic compounds with a nitro group (-NO₂) widely us! in industry—are convert! into amides in a single step. The reaction is highly efficient and does not generate by-products. The key element of the method is the book your list catalyst! a ruthenium cluster compound! Ru₃(CO)₁₂! which accelerates the reaction and enables it to be perform! with an exceptionally low metal content of just 16 ppm.
‘This means there are only 16 molecules of the catalyst per million molecules of the reagent. In fact! we use 62!500 times less catalyst than the amount of product!’ comments Mikhail Losev! student at the HSE Faculty of Chemistry.